Figure 3.

Predictive performance of weighted genetic risk scores (wGRSs).

The receiver operating characteristic (ROC) curves are plotted considering three models: wGRS based on only HLA-DRB1*1501 (solid black line), 102 non-human leukocyte antigen (HLA) loci (red dashed line) and 102 non-HLA loci + HLA-DRB1*1501 allele (green dotted line). The area under the curve (AUC) was calculated to assess the predictive capacity in (a) all multiple sclerosis (MS) probands, (b) sporadic MS and (c) multiplex MS compared to controls. (d) The prediction of multiplex MS patients from sporadic cases.