Table 1.
Demographic and clinical characteristics of patients with sporadic MS, multiplex MS and healthy controls.
| Controls (n = 2028) | Sporadic MS (n = 283) | Multiplex MS (all) (n = 286) | Multiplex MS (probands) (n = 169) | P valuec | |
|---|---|---|---|---|---|
| Female:male ratio (n:n) | 1.27:1 | 2.88:1 | 2.18:1 | 2.60:1 | NS |
| (1136:892) | (210:73) | (196:90) | (122:47) | ||
| Disease course (n) | N/A | RR 181 | RR 193 | RR 117 | NS |
| SP 53 | SP 41 | SP 25 | |||
| PP 49 | PP 52 | PP 27 | |||
| Relapsing-remitting onset (%) | 82.7 | 81.8 | 84 | NS | |
| Disease duration (years)a | N/A | 12.94 ± 8.80 | 15.50 ± 10.59 | 14.59 ± 9.77 | NS |
| Age at onset (years)a | N/A | 34.59 ± 10.43 | 32.82 ± 9.76 | 33.15 ± 9.21 | NS |
| EDSSb | N/A | 3.0 | 3.5 | 3.5 | NS |
| MSSSa | N/A | 4.75 ± 3.01 | 4.93 ± 2.86 | 4.81 ± 2.65 | NS |
MS: multiple sclerosis; EDSS: Expanded Disability Status Scale; MSSS: multiple sclerosis severity score; NS: not significant; N/A: not applicable; RR/SP/PP: relapsing–remitting, secondary progressive, primary progressive MS; SD: standard deviation.
a
For disease duration, age of onset and MSSS the mean and standard deviation are indicated.
b
For EDSS the median is reported.
c
For comparisons of sporadic MS with multiplex MS probands.