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. 2016 May 6;2:2055217316648721. doi: 10.1177/2055217316648721

Table 3.

AUC values for wGRS risk models in sporadic and multiplex MS patients.

All MS probands vs controls
 Sporadic MS vs controls
 Multiplex MS vs controls
 Sporadic MS vs multiplex MS
wGRS based on AUC 95% CI AUC 95% CI AUC 95% CI AUC 95% CI
HLA-DRB1*1501 0.63 0.61–0.66 0.60 0.57–0.63 0.68 0.65–0.72 0.58 0.55–0.63
102 non-HLA SNPs 0.66 0.63–0.68 0.64 0.60–0.67 0.69 0.65–0.73 0.55 0.49–0.60
102 non-HLA SNPs
+HLA-DRB1*1501 0.72 0.69–0.75 0.69 66–0.72 0.77 0.73–0.81 0.61 0.55–0.66

MS: multiple sclerosis; wGRS: weighted genetic risk score; AUC: area under the receiver operating curve; CI: confidence interval; HLA: human leukocyte antigen; SNP: single nucleotide polymorphism.