Table 10:
GRADE Evidence Profile for Impact on Therapeutic Decisions
| Number of Studies (Design) | Risk of Bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Upgrade Considerations | Quality |
|---|---|---|---|---|---|---|---|
| 1 (RCT) 3 (observational) | Serious limitationsa | Serious limitationsb | Very serious limitationsc | No limitations | None detected | None | ⊕ Very low |
Abbreviations: GRADE, Grading of Recommendations Assessment, Development, and Evaluation; RCT, randomized controlled trial.
a
Risk of bias assessment details are available in Appendix 3.
b
Results were inconsistent between the studies: some demonstrated an increase in the mean number of medications per patient by end of study, and others a decrease.
c
Outcomes were indirect measures of the outcome of interest (the impact of guided therapy on therapeutic decision-making).