Table 7:
GRADE Evidence Profile for Depression Score
| Number of Studies (Design) | Risk of Bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Upgrade Considerations | Quality |
|---|---|---|---|---|---|---|---|
| HAMD-17 | |||||||
| 1 (RCT) 2 (observational) | Serious limitationsa | No limitations | No limitations | Serious limitationsb | None detected | None | ⊕ Very low |
| QIDS-C16 | |||||||
| 2 (observational) | Serious limitationsa | No limitations | No limitations | Serious limitationsb | None detected | None | ⊕ Very low |
| PHQ-9 | |||||||
| 2 (observational) | Serious limitationsa | No limitations | No limitations | Serious limitationsb | None detected | None | ⊕ Very low |
Abbreviations: GRADE, Grading of Recommendations Assessment, Development, and Evaluation; HAMD-17, 17-item Hamilton Rating Scale for Depression; PHQ-9, 9-item Patient Health Questionnaire; QIDS-C16, 16-item Quick Inventory of Depressive Symptomatology, clinician rating.
a
Risk of bias assessment details are available in Appendix 3.
b
Wide confidence intervals impacted our confidence in the estimate of effect; experts advised that a clinically meaningful difference in HAMD-17 was two to three points.