Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
As part of its antimicrobial and tumoricidal properties, IFN-γ induces the enzymes GTP-CH-I, iNOS and IDO-1. Antioxidant compounds stabilize BH4, the cofactor of iNOS, thus supporting the production of NO˙, and also the life span of NO˙ is prolonged in a reductive milieu. NO˙ slows down IDO-1 activity, which may increase tryptophan availability. Antioxidants are also capable of suppressing Th1-type immune responses.
