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. Author manuscript; available in PMC: 2017 May 16.
Published in final edited form as: Methods Mol Biol. 2012;757:471–486. doi: 10.1007/978-1-61779-166-6_27

Figure 1.

Figure 1

The integrin family of adhesion of adhesion receptors and their ligands. There are 18 α and 8 β subunits which assemble to form 24 different heterodimers. Heterodimer composition confers ligand specificity. The main ligands for integrins in the extracellular space are extracellular matrix proteins, such as laminin, collagen, vitronectin and fibronectin. Moreover, integrins can also bind cellular counter-receptors (VCAM-1 or ICAM-1) and soluble molecules (fibrinogen).