Table 1. Descriptive, clinical data, choroidal thicknesses and volume for eyes of patients with Parkinson’s disease and from healthy controls (validating population).
| PD PATIENTS | CONTROLS | P* | |
|---|---|---|---|
| Number of eyes | 40 | 40 | - |
| Age (years) | 69.8 ± 6.5 | 68.6 ± 7.2 | 0.137 |
| Sex (men/women) | 26/14 | 26/14 | 0.901 |
| Spherical Equivalent (D) | 0.14 ± 1.76 | 0.13 ± 1.88 | 0.388 |
| Number of myopic subjects (%) ** | 18 (45%) | 17 4(42.5%) | 0.404 |
| Number of hyperopic subjects (%)** | 6 (15%) | 6 (15%) | 0.945 |
| BCVA (LogMAR) | 0.11 ± 0.17 | 0.03 ± 0.16 | 0.005 |
| IOP (mm Hg) | 16.5 ± 2.0 | 16.2 ± 2.8 | 0.439 |
| Disc area (mm2) | 1.92 ± 0.37 | 1.89 ± 0.37 | 0.309 |
| Unified Parkinson Disease Rating Scale | 25.1 ± 5.4 | - | - |
| Hoehn and Yahr Scale | 2.7 ± 0.8 | - | |
| Disease duration (years) | 6.7 ± 2.3 | - | - |
| Choroidal thickness (μm) | |||
| Zone 2 | 126.89 ± 11.23 | 96.53 ± 9.55 | <0.0001 |
| Zone 3 | 152.75 ± 16.00 | 121.39 ± 12.10 | <0.0001 |
| Zone 4 | 190.21 ± 12.16 | 156.69 ± 12.44 | <0.0001 |
| Zone 5 | 213.21 ± 11.83 | 186.64 ± 9.47 | <0.0001 |
| Total | 163.01 ± 29.90 | 131.51 ± 30.22 | <0.0001 |
| Number of peripapillary cubes | |||
| 70–104 μm thick | 0 | 116 | <0.0001 |
| 105–139 μm thick | 165 | 258 | <0.0001 |
| 140–174 μm thick | 202 | 175 | <0.0010 |
| ≥175 μm thick | 221 | 39 | <0.0001 |
Comparison of the choroidal thicknesses in the four established zones in the control group and Parkinson’s disease patients, and comparison between groups. Comparison of the number of peripapillary cubes with a thickness from 70 to 104 μm (zone 2), from 105 to 139 μm (zone 3); from 140 to 174 μm (zone 4), and ≥ 175 μm (zone 5). Zone 1 corresponds to the optic nerve head and was not included in the analysis.
* p: level of statistical significance in comparison between the two groups using Student’s t-test (except for sex, chi-square test). Data are mean ± standard deviation. Bold text indicates statistically significant results (p<0.05).
** Subjects were considered myopic when spherical equivalent was < -1D. Subjects were considered hyperopic when spherical equivalent was >1D. Abbreviations: PD, Parkinson´s disease; D, diopters; BCVA, best-corrected visual acuity; IOP, intraocular pressure.