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. 2017 May 16;12(5):e0177605. doi: 10.1371/journal.pone.0177605

Fig 3. Oleate, but not palmitate, increases the expression of G protein-coupled receptor FFAR1 mRNA and amplifies the acute secretory response of GLP-1 producing cells to fatty acids.

Fig 3

Whereas 0.125 mM palmitate significantly reduced GLUTag proglucagon and FFAR1 (GPR40) / FFAR3 (GPR43) mRNA expression after 48h (A), oleate exposure significantly increased the expression of proglucagon / FFAR 1 (GPR40) and FFAR3 (GPR43) mRNA after 24h / 48h respectively (B). GLP-1 secretion in response to 0.5 mM palmitate was increased 2-fold following a 48h exposure to 0.125mM oleate (C). Comparisons between groups were made by a one-way ANOVA, and Student-Newman-Keul’s post hoc test. Bars represent mean ± SEM. *, p<0.05; ***, p<0.001 compared with controls. #, p<0.05 compared with palmitate-treated cells.