Table 2. Baseline Cognitive Function Characteristics of Men With AAMI in the Cognitive Function Trial and in All Men Enrolled in the Testosterone Trials.
| Men With AAMI in the Cognitive Function Trial | All Men in the Testosterone Trials | |||
|---|---|---|---|---|
| Placebo (n = 246) | Testosterone (n = 247) | Placebo (n = 394) | Testosterone (n = 394) | |
| Performance, Mean (SD) | ||||
| Mini-Mental State Examination | 28.3 (1.8) | 28.3 (1.7) | 28.4 (1.7) | 28.4 (1.7) |
| Gait speed, m/s | 1.1 (0.2) | 1.1 (0.2) | 1.1 (0.2) | 1.1 (0.2) |
| Derogatis Interview for Sexual Functioninga | 13.3 (7.7) | 13.5 (7.8) | 14.0 (7.8) | 13.9 (7.7) |
| FACIT scaleb | 36.1 (8.8) | 36.6 (8.8) | 36.8 (8.8) | 37.0 (8.6) |
| PANASc | ||||
| Positive affect | 15.8 (3.4) | 15.9 (3.4) | 16.0 (3.6) | 16.2 (3.6) |
| Negative affect | 7.2 (2.5) | 7.2 (2.5) | 7.2 (2.7) | 7.1 (2.5) |
| PHQ-9 (score range, 0 to 21) | 5.5 (3.9) | 5.7 (4.1) | 5.3 (4.0) | 5.4 (3.9) |
| Cognitive Outcomes, Mean (SD) | ||||
| Delayed paragraph recall (score range, 0 to 50)d | 14.4 (6.4) | 14.0 (6.6) | 15.7 (6.6) | 15.3 (6.8) |
| Benton Visual Retention Test Errors (score range, 0 to −26)e | −8.2 (3.1) | −8.2 (3.2) | −7.3 (3.8) | −7.5 (3.9) |
| Card Rotation Test (score range, −80 to 80) | 30.0 (14.8) | 28.7 (14.1) | 31.4 (15.1) | 29.7 (15.0) |
| Trail-Making Test, s | ||||
| A (maximum score, 300 seconds) | 42.3 (16.8) | 42.2 (18.2) | 41.7 (16.7) | 42.1 (20.4) |
| B (maximum score, 300 seconds) | 119.0 (60.1) | 128.4 (72.0) | 114.9 (59.6) | 125.0 (71.0) |
| B − A (range, −290 to 290)f | 76.7 (54.2) | 86.4 (64.8) | 73.3 (52.2) | 83.1 (63.2) |
| 3MSE (score range, 0 to 100) |
93.0 (4.9) | 92.3 (6.6) | 93.4 (4.9) | 92.8 (6.5) |
| MAC-Q (score range, 6 to 30) |
24.9 (3.8) | 25.3 (3.9) | 23.5 (5.1) | 23.3 (5.3) |
| Immediate paragraph recall (score range, 0 to 50)g | 18.6 (6.2) | 18.3 (6.5) | 19.7 (6.3) | 19.5 (6.6) |
Abbreviations. 3MSE, Modified Mini-Mental State Examination; AAMI, Age-associated memory impairment; FACIT, Functional Assessment of Chronic Illness Therapy Scale; MAC-Q, Memory Assessment Clinics Questionnaire; PANAS, Positive and Negative Affect Schedule; PHQ-9, Patient Health Questionnaire-9.
The Derogatis Interview for Sexual Functioning measures sexual desire.
The FACIT scale measures fatigue.
PANAS is a 20-item, self-reported measure of mood by 2 scales (positive and negative affect).
Delayed paragraph recall was measured with the Wechsler Memory Scale-Revised Logical Memory II test.
BVRT error scores were inverted so that higher scores reflect better performance for all cognitive outcomes, except Trail-Making Test A, B, and B − A wherein higher time in seconds reflects poorer performance.
The only significant difference between testosterone and placebo groups was Trail-Making Test B and Trail-Making Test B − A, wherein scores were better in the placebo than testosterone group for all men (P < .05).
Immediate paragraph recall was measured with the Wechsler Memory Scale-Revised Logical Memory I test.