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(A) PAD4 can convert methylated or unmethylated arginine to citrulline. The reaction then blocks arginine methylation from occurring on histone tails. (B) JMJD6 is an Fe(II)- and 2-oxoglutarate (α-KG)-dependent dioxygenase which removes methyl groups from symmetrical dimethyl H4R3 (SDMA) or asymmetrical dimethyl H4R3 (ADMA) to generate monomethylarginine (H4R3me1).
