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. Author manuscript; available in PMC: 2017 May 16.
Published in final edited form as: Crit Rev Immunol. 2015;35(1):49–57. doi: 10.1615/critrevimmunol.2015012558

FIG. 1.

FIG. 1

Sequential development of B cells in the bone marrow and maturation in the spleen. Differential expression of cell-surface markers has allowed delineation of the various B-cell phenotypes that emerge as the hematopoietic precursor B cells derived from fetal liver progress from the pro-B cells following induction (RAG1 and RAG2) and production of the heavy chain IG. Immature B cells exit the bone marrow after subjection to central tolerance mechanisms that eliminate autoreactive immature B cells. After leaving the bone marrow, T1 and T2 immature B cells are further subjected to peripheral tolerance mechanisms before full maturation into MZ, follicular, or plasma B cells. (RAG) Recombination-activating gene; (T1) transitional 1; (T2) transitional 2; (MZ) marginal zone; (FO) follicular-type-B cell.