Table.

Comparison of genetic characteristics between CHIP, CCUS, and MDS.

	CHIP Unselected Population	CCUS At Diagnosis	CCUS Prior to MDS/AML Progression	MDS All Risk Groups
Commonly Mutated Genes	DNMT3A, TET2,ASXL1, PPM1D, JAK2, TP53	TET2, DNMT3A,ASXL1, SRSF2, TP53	TET2, SRSF2, ASXL1, U2AF1, DNMT3A	SF3B1, TET2, ASXL1, SRSF2, DNMT3A
Mean # of Mutations	~1	~1.6	~2	~2.6
Typical VAF	9–12%	30–40%	~40%	30–50%
Incidence	About 10–15% of 70 year-olds	About 35% of ICUS	About 90% of ICUS	May be <50% of cytopenic patients