Table 5. Multivariate Analysis of Predictors of Aerobic Capacity.

	Aerobic Capacity (Peak V̇O2 ml/kg/min)
N=54	Model 1a	Model 2b
Variable	β	β	95% CI
Constant	0.44	4.35	[-4.41, 13.10]
% ASC Methylation	2.73**	2.30**	[0.91, 3.70]
LVEF		-0.78*	[-0.15, -0.002]
Gender†		2.42*	[0.07, 4.76]
R2	.22	.40
F	12.90**	9.72***
ΔR2		.18
ΔF		6.54**
	Aerobic Capacity (Peak V̇O2 ml/kg/min)
N=54	Model 1c	Model 2d
Variable	β	β	95% CI
Constant	20.38***	21.51***	[16.73, 26.29]
IL-1β	-2.15**	-1.91**	[-3.32, -0.51]
LVEF		-0.085**	[-0.17, -.004]
Gender†		2.62*	[0.12, 5.12]
R2	.15	.35
F	8.47**	8.20***
ΔR2		.20
ΔF		6.99**

ASC = apoptosis associated speck-like protein containing a caspase recruitment domain.

LVEF = left ventricular ejection fraction. CI = confidence interval.

^*p<.05.

^**p<.01

^***p<.001

^†Female is coded as 0.

^aModel 1 is the direct effect of percent ASC Methylation not adjusted for covariates.

^bModel 2 considered age, gender, six-minute walk test, and BMI covariates for inclusion in the final model in addition to percent ASC Methylation: stepwise variable selection used.

^cModel 1 is the direct effect of IL-1β not adjusted for covariates.

^dModel 2 considered age, gender, six-minute walk test, and BMI covariates for inclusion in the final model in addition to IL-1β: stepwise variable selection used.