Fig. 1.
HIF-1α maintenance in normoxia, HIF-1α subunits undergo oxygen-dependent degradation via PHD hydroxylation, followed by VHL complex ubiquitination and proteasomal degradation.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.