. Author manuscript; available in PMC: 2018 Jun 1.

Published in final edited form as: Crit Care Med. 2017 Jun;45(6):980–988. doi: 10.1097/CCM.0000000000002409

Table 2.

Association of case volume and adherence to all three processes of care studied (measurement of lactate within the first day, use of norepinephrine as initial vasopressor, and avoidance of hydroxyethyl starch products) with mortality in the septic shock cohort stratified by number of acute organ failures

Whole Septic Shock Cohort
	Case Volume	Processes of Care	Processes of Care (controlling for case volume)
1st Quartile	Reference	Reference	Reference
2nd Quartile	1.0 (0.85–1.2)	0.99 (0.88–1.1)	0.99 (0.88–1.1)
3rd Quartile	0.96 (0.82–1.1)	0.86 (0.76–0.98)^a	0.87 (0.76–0.99)^a
4th Quartile	0.95 (0.82–1.1)	0.81 (0.70–0.94)^a	0.81 (0.71–0.94)^a

Single Organ Failure

	Case Volume	Processes of Care	Processes of Care (controlling for case volume)
1st Quartile	Reference	Reference	Reference
2nd Quartile	0.89 (0.68–1.2)	0.93 (0.79–1.1)	0.96 (0.81–1.1)
3rd Quartile	0.94 (0.73–1.2)	0.90 (0.75–1.1)	0.93 (0.78–1.1)
4th Quartile	0.77 (0.60–0.99)^a	0.82 (0.68–0.99)^a	0.85 (0.70–1.0)

Two or More Organ Failures

	Case Volume	Processes of Care	Processes of Care (controlling for case volume)
1st Quartile	Reference	Reference	Reference
2nd Quartile	1.04 (0.88–1.2)	0.99 (0.89–1.1)	0.99 (0.89–1.1)
3rd Quartile	0.99 (0.83–1.2)	0.88 (0.77–1.0)	0.88 (0.77–1.0)
4th Quartile	0.98 (0.83–1.2)	0.82 (0.71–0.95)^a	0.82 (0.71–0.95)^a

All models adjusted for age, sex, race, year of hospitalization, geographic location, teaching hospital status, specialty of attending physician, point of origin, prevalent comorbidities, intensive care unit stay, mechanical ventilation during the first hospital day, acute organ failures, and source of infection.

Statistically significant adjusted odds ratio.