Table 3.
Clinical Care in Moderate-Severe TBI Patientsa
| Variable | No systolic dysfunction (n=25) | Systolic dysfunction (n=7) | p |
|---|---|---|---|
| Age (years) | 39.1 (13.7) | 27.1 (5.6) | 0.03 |
| Male Gender | 21 (84%) | 6 (86%) | 0.91 |
| Glasgow Coma Scale | |||
| Admission GCS | 5.7 (2.5) | 3.4 (1.1) | 0.03 |
| Highest GCS (within 24 hours) | 9.3 (2.1) | 7.7 (5.1) | 0.22 |
| Lowest GCS (within 24 hours) | 4.8 (2.0) | 4.9 (3.8) | 0.99 |
| Admission Hematocrit (%) | 38.0 (5.2) | 37.9 (6.2) | 0.96 |
| Systolic Blood Pressure (mmHg) | |||
| Admission SBP | 131.9 (25.2) | 133.9 (19.4) | 0.85 |
| Lowest SBP in first 24 hours | 98.4 (12.6) | 96.1 (19.5) | 0.71 |
| Hypotension (SBP≤90) in first 24 hours | 8 (32%) | 3 (43%) | 0.59 |
| Hypertension (SBP≥140) in first 24 hours | 19 (76%) | 6 (86%) | 0.58 |
| Admission Oxygen Saturation (%) | 96.4 (3.2) | 92.9 (8.1) | 0.09 |
| Vasopressorb | 4 (16%) | 2 (29%) | 0.45 |
| Phenylephrine | 3 (12%) | 1 (14%) | 0.87 |
| Maximum Dose (mcg/kg/min) | 1.5 (0) | 15 (0) | n/a |
| Norepinephrine | 1 (4%) | 1 (14%) | 0.32 |
| Maximum Dose (mcg/kg/min) | 0.2 (0) | 0.2 (0) | n/a |
| Anti-Hypertensive Useb | 0 (0%) | 0 (0%) | n/a |
| Intracranial Proceduresb | |||
| ICP monitor placement | 12 (48%) | 4 (57%) | 0.67 |
| Need for intracranial surgery | 9 (36%) | 3 (43%) | 0.74 |
| Mechanical Ventilationb | 25 (100%) | 7 (100%) | n/a |
| Propofol Sedationb | |||
| Any Use | 25 (100%) | 7 (100%) | n/a |
| Maximum Dose (mcg/kg/min) | 43.6 (24.9) | 53.6 (21.0) | 0.34 |
| Osmotherapyb | |||
| Mannitol | 10 (40%) | 4 (57%) | 0.42 |
| Hypertonic Saline | 4 (16%) | 3 (43%) | 0.13 |
| Fluid Balance (mL)b | |||
| Intake | 5395 (2558.0) | 6776 (4692.4) | 0.31 |
| Output | 3098 (1440.8) | 3688 (1269.1) | 0.33 |
| Fluid Balance | 2297 (2404.6) | 3088 (4202.6) | 0.52 |
a
Values are mean(SD) for continuous variables and n(%) for categorical variables.
b
In first 24 hours after admission
GCS=Glasgow Coma Scale; SBP = systolic blood pressure; mmHg = millimeters of mercury; mL = milliliters