Table 1:

Hazard ratios between perivascular spaces and outcome events^a

	All Deaths	Vascular Death	Myocardial Infarction	Any Stroke	Any Vascular Event
Small PVS score
Continuously	1.01, 0.98–1.04	1.06, 1.01–1.11	1.03, 0.98–1.08	1.04, 0.98–1.10	1.04, 1.01–1.07
Categorically
First tertile	Reference	Reference	Reference	Reference	Reference
Second tertile	0.72, 0.53–0.96	1.13, 0.68–1.87	2.21, 1.10–4.45	0.96, 0.54–1.72	1.23, 0.86–1.75
Third tertile	0.95, 0.71–1.27	1.34, 0.80–2.23	1.81, 0.89–3.71	1.51, 0.88–2.57	1.38, 0.97–1.98
Large PVS score
Continuously	0.99, 0.90–1.10	0.99, 0.89–1.10	1.10, 0.93–1.04	1.07, 0.88–1.28	1.08, 0.97–1.21
Categorically
≤1	Reference	Reference	Reference	Reference	Reference
≥2	1.02, 0.77–1.36	1.03, 0.77–1.67	1.40, 0.83–2.36	0.99, 0.60–1.61	1.07, 0.78–1.48

^aModels are adjusted for head size, motion artifacts, age, sex, ethnicity, vascular risk factors at MRI and during follow-up (hypertension, hypercholesterolemia, diabetes, and smoking), prior cardiac disease, and body mass index. Data are hazard ratios and 95% CIs.