Table 3.
Serum hormone levels at baseline and follow-up
| Medians (interquartile range) | |||||
|---|---|---|---|---|---|
| Baseline | 12 weeks | 24 weeks | 48 weeks | % Reduction (95% CI), p-valueƚ |
|
| Testosterone (ng/dL) | |||||
| Subcapsular orchiectomy | 425.1 (324.2,562.7) |
13.8 (10.0, 17.7) |
13.7 (11.0, 17.2) |
13.8 (11.8,17.7) |
97 (96.4, 97.2), p < .001 |
| Triptorelin | 351.6 (262.8,443.8) |
8.6* (8.6*, 10.7) |
10.1 (8.6*, 12.4) |
9.2 (8.6*, 11.5) |
97 (96.8, 98.0), p < .001 |
|
Androstenedione (nmol/L) |
|||||
| Subcapsular orchiectomy | 2.26 (1.81, 2.67) |
1.46 (1.05, 1.74) |
1.23 (1.00*, 1.67) |
1.46 (1.00*, 1.98) |
40 (33.1, 46.6), p < .001 |
| Triptorelin | 2.12 (1.61, 3.12) |
1.22 (1.00*, 1.69) |
1.12 (1.00*, 1.91) |
1.42 (1.00*, 1.97) |
40 (33.2, 47.5), p < .001 |
|
DHEAS (nmol/L) |
|||||
| Subcapsular orchiectomy | 1690 (1093, 2073) |
1370 (823, 1815) |
1200 (806, 2125) |
1370 (1085, 2160) |
17 (8.8, 24.8), p < .001 |
| Triptorelin | 1950 (1310, 2560) |
1290 (1000, 2130) |
1590 (800, 2290) |
1470 (886, 2540) |
22 (13.9, 30.6), p < .001 |
|
17-hydroxyprogesterone (nmol/L) |
|||||
| Subcapsular orchiectomy | 2.48 (1.61, 2.81) |
1.00* (1.00*, 1.05) |
1.00* (1.00*, 1.00*) |
1.00* (1.00*, 1.11) |
65 (58.5, 72.1), p < .001 |
| Triptorelin | 1.82 (1.50, 2.26) |
1.00* (1.00*, 1.00*) |
1.00* (1.00*, 1.05) |
1.00* (1.00*, 1.15) |
60 (50.1, 69.5), p < .001 |
| SHBG (nmol/L) | |||||
| Subcapsular orchiectomy | 53 (42, 72) | 57 (46, 67) | 57 (49, 74) | 56 (48, 75) | −3 (−13.5, 6.7), p = 0.502 |
| Triptorelin | 46 (34, 53) | 44 (33, 58) | 46 (38, 59) | 47 (35, 55) | 0 (−10.1, 10.7), p = 0.961 |
| Estradiol (nmol/L) | |||||
| Subcapsular orchiectomy | 0.11 (0.10, 0.13) |
0.05 (0.04*, 0.06) |
0.06 (0.05, 0.07) |
0.06 (0.04*, 0.08) |
54 (48.1, 60.4), p < .001 |
| Triptorelin | 0.10 (0.09, 0.11) |
0.04 (0.04*, 0.06) |
0.05 (0.04*, 0.07) |
0.05 (0.04*, 0.06) |
56 (49.0, 63.0), p < .001 |
| FSH (IU/L) | |||||
| Subcapsular orchiectomy | 9.2 (5.8, 13.5) |
55.3 (39.5, 64.8) |
60.4 (45.8, 71.4) |
Not measured |
−485 (−600.2, −370.2), p < .001 |
| Triptorelin | 9.4 (5.6, 13.0) |
4.3 (3.0, 5.6) |
4.6 (3.3, 5.4) |
Not measured |
55 (45.4, 64.3), p < .001 |
| LH (IU/L) | |||||
| Subcapsular orchiectomy | 5.0 (3.2, 7.5) |
31.3 (25.7, 34.4) |
32.3 (22.0, 37.8) |
Not measured |
−500 (−610.0, −389.4), p < .001 |
| Triptorelin | 4.0 (2.8, 6.1) |
0.3* (0.3*, 0.3*) |
0.3* (0.3*, 0.3*) |
Not measured |
98 (97.2, 99.6), p < .001 |
Ƚ
Within-group % reductions in hormone levels estimated by longitudinal Tobit regressions of log hormone levels versus post-treatment indicator.
*
Censored at lower reporting limit of the assay.
DHEAS: Dehydroepiandrosterone sulfate. SHBG: Sex hormone binding globulin. FSH: follicle stimulating hormone. LH: Luetinizing hormone.