Fig. 3.

The dose-related effects of 2-PMPA (10 and 30 mg/kg) on the place preference induced by MDPV (2 mg/kg). In Figure 3a, the data (n = 10–11 per group) are presented as a difference score (difference in time spent in the less-preferred compartment between post-test and pre-test). Results showed that the increase in place preference produced by MDPV was significantly reduced by 2-PMPA (p < 0.05). In Figure 3b, the data (n = 8 per group) are expressed as a percentage of the MDPV (2 mg/kg) values. 2-PMPA dose-dependently reduced MDPV-induced place preference with a significant effect obtained at 30 mg/kg (p < 0.05), but not 10 mg/kg (p > 0.05). Data are shown as mean + S.E.M. ***p < 0.001, **p < 0.01, *p < 0.05 relative to MDPV + vehicle. SAL, saline; VEH, vehicle