Fig. 5.

The dose-related effects of NAAG (10, 100 and 500 μg/10 μl) on the place preference produced by MDPV (2 mg/kg). Data (n = 10–15 per group) are presented as a difference score (difference in time spent in the less-preferred compartment between post-test and pre-test). NAAG dose-dependently reduced MDPV-induced CPP, with a significant effect observed at 100 and 500 μg/10 μl (both p < 0.05), but not at 10 μg/10 μl (p > 0.05). There was no significant effect of the high dose of NAAG (i.e. 500 μg/10 μl) on place preference relative to saline, when only saline was used during conditioning (n = 7–8 per group) (Figure 5 inset; p > 0.05). Data are shown as mean + S.E.M. *p < 0.05 relative to MDPV alone. SAL, saline