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. Author manuscript; available in PMC: 2017 Jun 19.
Published in final edited form as: Mucosal Immunol. 2016 Nov 16;10(4):971–982. doi: 10.1038/mi.2016.98

Figure 1. SAMP × NOD2−/− mice show decreased severity of inflammation compared to SAMP WT mice.

Figure 1

(A) PCR genotyping of mouse tail DNA showing the generation of SAMP × NOD2−/− mice using speed congenic techniques. (B) Ileal total inflammatory scores at different time points (4, 10 and 20-30-wk old), as determined by the sum of chronic inflammation, active inflammation, villous distortion and mononuclear inflammation. ** P < 0.001 (n=17-24), unpaired Student’s t test; data are represented as mean ± SEM. (C) Representative histopathological sections show significant villous blunting and a significant increase of inflammatory cells in the lamina propria of 20-30-wk old SAMP WT compared to SAMP × NOD2−/− mice. (D) MPO activity in ilea of SAMP WT and SAMP × NOD2−/− mice at 30 wks of age. * P < 0.05 (n=13), pairwise Mann–Whitney test; data are represented as mean ± SEM.

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