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. Author manuscript; available in PMC: 2018 Apr 12.
Published in final edited form as: Cell Host Microbe. 2017 Apr 12;21(4):494–506.e4. doi: 10.1016/j.chom.2017.03.008

Figure 4. Cells containing HIV-1def can be recognized by HIV-1-specific CTLs.

Figure 4

Flow cytometry showing %degranulated CTLs (CD8+CD107a+) from 2 Gag-specific clones (A–B), 2 Nef-specific clones (C–D) and a CMV-specific clone (E) upon co-culture with autologous CD4+ T cells transfected with HIV-1def plasmids. NL4-3 has an anchor residue mutation (K162Q) at the IK9 epitope making it not susceptible to CTL recognition (A). Each target was tested in independent quadruplets shown in mean ± SEM. P values were calculated by one-way ANOVA with Dunnett’s multiple comparison test. *P<0.05, **P<0.01, ***P<0.001, **** P<0.0001. See also Figure S7.