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Characteristics of Van-HPMCs spray-dried microparticles
| Sample | Spray dryer feed composition | Obtained microparticles | |||
|---|---|---|---|---|---|
| HPMC/drug ratio | HPMC (µg/ml) | Vancomycin (µg/ml) | Particle size (µm) | Surface appearance | |
| H1 | – | 10 | – | 3.0–8.0 | Completely collapsed |
| H2 | 4/1 | 10 | 2.5 | 4.0–22 | Spherical—collapsed |
| H3 | 2/1 | 10 | 5.0 | 3.0–18 | Spherical—rough |
| H4 | 1/1 | 10 | 10 | 2.0–13 | Spherical—smooth |
| H5 | 1/1 | 5.0 | 5.0 | 2.5–10 | Smooth |
| H6 | 1/1 | 0.5 | 0.5 | 1.5–6.4 | Spherical and uniform |
