Table 3.
Determinants of coexisting BK virus nephropathy and acute rejection.
| Factor | Crude OR | 95% CI | p Value | Adjusted OR# | 95% CI | p Value | ||
|---|---|---|---|---|---|---|---|---|
| Lower | Upper | Lower | Upper | |||||
| Tacrolimus use (reference: no) | 0.400 | 0.022 | 7.201 | 0.534 | 0.365 | 0.017 | 8.021 | 0.522 |
| Tacrolimus serum trough level within 3 months prior to renal biopsy | ||||||||
| Mean (ng/mL) | 0.770 | 0.499 | 1.188 | 0.237 | 0.839 | 0.544 | 1.294 | 0.428 |
| Standard deviation (ng/mL) | 1.521 | 0.663 | 3.489 | 0.322 | 1.825 | 0.711 | 4.680 | 0.211 |
| Coefficient of variance (%) | 1.079 | 1.007 | 1.156 | 0.031* | 1.068 | 1.003 | 1.137 | 0.039* |
| Sirolimus use (reference: no) | 14.875 | 2.198 | 100.656 | 0.006* | 10.490 | 1.429 | 76.975 | 0.021* |
| Sirolimus serum trough level within 3 months prior to renal biopsy | ||||||||
| Mean (ng/mL) | 1.239 | 0.631 | 2.429 | 0.534 | 1.377 | 0.637 | 2.979 | 0.416 |
| Standard deviation (ng/mL) | 1.741 | 0.691 | 4.387 | 0.239 | 1.706 | 0.568 | 5.120 | 0.341 |
| Coefficient of variance (%) | 1.065 | 0.949 | 1.194 | 0.283 | 1.067 | 0.929 | 1.226 | 0.356 |
#Adjusted models were adjusted for a propensity score consisting of recipient age, gender, deceased donor, transplantation vintage, diabetes mellitus, hypertension, congestive heart failure, albumin, estimated glomerular filtration rate according to the CKD-EPI formula, and absolute lymphocyte count. Abbreviations: OR, odds ratio; CI, confidence interval. *p < 0.05.