Table 3.

Genotype-specific amino acid variants in PreS1 region.

Genotypea	Typical amino acid variants on PreS1 b
A	48I, 54A, 67L, 74I, 89S, 90T, 91I
B	35K, 39E, 45L, 48H, 56H, 87S
C	10Q
D	39A, 51T, 65L, 86Q, 91N, 114N
E	16H, 19T, 39R, 45H, 53T, 84M, 86K, 109T
F	8T, 47K, 84V
G	25L, 48K, 51P, 81S, 84T
H	8A, 47T, 88S, 90P
A + B	10K
A + C	35G, 57Q
B + D	54D, 108L
C + D	60A
D + G	19S
E + G	3L, 4S, 5W, 6T, 7V, 9L, 10E, 11W, 14K, 63Y
F + H	3A, 4P, 5L, 7T, 10R, 33L, 39S, 40S, 54M, 62G, 100R, 104K, 108V
A + B + C	3G, 4W, 5S, 7K, 14T, 88V
A + C + E	51H
A + C + G	39N, 115S
B + F + H	51N
C + E + G	54E
D + E + G	18T, 38T
D + F + H	14Q

^aThe viral genotype(s) and their specific PreS1 amino acid residues are listed. Only genotype-specific variants in three or less genotypes are showed.

^bThe genotype-specific amino acid variants are represented by their positions on PreS1 peptide (from 1st to 119th residues) and the amino acid symbol.