Isotropic medium: example of unpinning and repinning of the pinned spiral during overdrive pacing (Tp=0.9Tsp) with t1=360 ms, after the delivery of the third pulse. In (a), the application of the electric field induces areas of depolarization and hyperpolarization at the boundaries of the ischaemic zone. Since the excitation threshold is exceeded, a new wave (N) is generated. One of the ends of the newly initiated wave (A) collides with the original spiral and annihilates it. The other end (F) travels counterclockwise around the boundary of the obstacle (b), but its propagation is inhibited by the refractory tail of the original spiral wave (c) and (d). This causes the temporary detachment of the wave (G) (e), followed by reattachment, also called repinning (f). The snapshots are taken at 15 ms (a), 70 ms (b), 170 ms (c), 270 ms (d), 300 ms (e) and 385 ms (f) after the delivery of the pulse. (Online version in colour.)