Table 6.

Repeated measures ANOVA for long-term development of various skills in children with mitochondrial diseases (n = 18).

DQ	Difference	p	Difference (95% confidence interval)	Post hoc
Total		<0.001
	Pre-Dx		16.1 (6.3–25.8)	0.001**
	Dx-post		7.7 (2.4–13.0)	0.004**
Gross motor		<0.001
	Pre-Dx		12.8 (1.8–23.8)	0.020*
	Dx-post		6.8 (0.6–14.3)	0.080
Fine motor		<0.001
	Pre-Dx		16.2 (2.2–30.2)	0.020*
	Dx-post		7.7 (1.0–16.4)	0.095
Social–personal		<0.001
	Pre-Dx		16.3 (0.8–31.8)	0.037*
	Dx-post		11.4 (0.7–23.5)	0.071
Language		<0.001
	Pre-Dx		20.7 (6.1–35.2)	0.005**
	Dx-post		4.3 (2.8–11.5)	0.381
Cognitive-adaptive		0.001
	Pre-Dx		15.3 (1.0–29.5)	0.033*
	Dx-post		6.4 (2.7–15.6)	0.240

General linear model, repeated measures with Bonferroni adjustment: *p < 0.05, **p < 0.01. DQ, developmental quotient; pre, pre-diagnostic evaluation; post, post-diagnostic evaluation; Dx, diagnostic evaluation.