Table 2.
Characteristics of children with and without cough down regulation during exercise.
| Cough down regulation | No n = 6 | Yes n = 24 | p |
|---|---|---|---|
| Males/females, n | 4/2 | 13/11 | ns |
| Age (years) | 9.5 (9.0–11.0) | 10.0 (8.0–12.2) | ns |
| Height (cm) | 140.5 (139.0–148.0) | 140.0 (130.5–149.5) | ns |
| Weight (kg) | 34.0 (31.0–37.0) | 33.0 (27.5–37.0) | ns |
| Expired NO (ppb) | 10.5 (9.0–20.0)** | 16.5 (14.0–19.0)* | ns |
| C2 (μmol/l) | 5.2 (0.6–9.8) | 4.9 (2.4–9.8) | ns |
| C5 (μmol/l) | 97.7 (19.5–312.5) | 39.1 (9.8–117.2) | ns |
| FVC (% predicted) | 106.0 (97.0–109.0) | 101.5 (92.0–113.0) | ns |
| FEV1 (% predicted) | 108.5 (95.0–112.0) | 102.5 (90.0–108.0) | ns |
| SpO2 (%) | |||
| - at rest | 98.0 (97.0–99.0) | 98.0 (98.0–99.0) | ns |
| - 5th min after exercise | 98.0 (97.0–99.0) | 98.0 (98.0–99.0) | ns |
| Heart rate (bpm) | |||
| - at rest | 86.0 (74.0–97.0) | 90.0 (80.0–100.0) | ns |
| - during exercise | 168.25 (161.0–169.0) | 165.0 (162.0–171.0) | ns |
| - 5 min after exercise | 100.5 (90.0–120.0) | 108.0 (99.0–111.0) | ns |
| Incidence of | |||
| - passive smoking | 0 (0.0) | 4 (16.7) | ns |
| - personal history of atopic disease other than asthma | 2 (33.3) | 2 (8.3) | ns |
| - family history of atopy | 5 (83.3) | 10 (41.7) | ns |
| - family history of asthma | 0 (0.0) | 5 (20.8) | ns |
Data are median (IQR) or n (%). C2: capsaicin concentration that provoked at least 2 coughs, C5: capsaicin concentration that provoked at least 5 coughs. Between groups comparisons were performed using non parametric Mann-Whitney test for numeric variables and chi-square test (Fisher Exact test if n < 5) for categorical variables. ns, non-significant.
*
n = 18;
**
n = 4.