Skip to main content
. 2017 May 2;2017:3160360. doi: 10.1155/2017/3160360

Figure 3.

Figure 3

Role of Ras signaling in HIV-1 Tat-induced changes in NEP. Exposure to HIV-1 Tat resulted in marked decreases in NEP protein (a) and mRNA (b) and weaker immunoreactivity (c) compared with the control group. Prior to HIV-1 Tat exposure, cells were pretreated with 5 μmol/L FTS for 3 h with FTS in the culture medium. NEP protein and mRNA levels and immunoreactivity significantly increased with coexposure to FTS and HIV-1 Tat compared with the HIV-1 Tat group. Data are expressed as means ± standard error of the mean (n = 3 for (a), n = 5 for (b)). ∗p < 0.05, ∗∗p < 0.01 versus that in the control; #p < 0.05, ##p < 0.01 versus that in HIV-1 Tat.