Figure 4.

Large-Scale Reorganization in One-Handers, Potential Mechanism

(A) Top: resting-state global signal was defined as the averaged time course of gray-matter voxels (red) across the entire brain (illustrated in one participant). Bottom: one-handers’ missing-hand territory (white bars) showed increased coupling with the global signal compared to controls’ nondominant-hand territory (gray bars).

(B) Top: illustration of two voxels (red) placed over the bilateral hand knobs, used to extract absolute GABA concentrations using MR spectroscopy. Bottom: one-handers’ missing-hand territory showed reduced GABA concentrations compared to controls’ nondominant-hand territory, suggesting reduced inhibition in the missing-hand territory. FC, functional connectivity. Other annotations are as in Figure 2. Error bars depict SEMs.

See also Figure S2.