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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Neuropharmacology. 2016 Oct 25;113(Pt A):426–433. doi: 10.1016/j.neuropharm.2016.10.025

Figure 3. PICK1 is not necessary for a Li+ treatment-induced increase in surface GluA2.

Figure 3

a) Representative immunoblots of cell extracts from PICK1 knockdown (KD) cultured hippocampal neurons showing that PICK1 shRNA significantly reduced PICK1 protein levels in these neurons. b) Representative confocal images of hippocampal neurons treated with NaCl or LiCl in the presence of absence of PICK1 shRNA showing surface GluA2 (green) and total GluA2 (red). Scale bar indicates 10μm. Higher magnification images of highlighted dendrites are shown below. Summary graphs show that reduction of PICK1 levels had no effect of LiCl treatment on surface GluA2 levels (n=4 neurons in each condition, *p<0.05 and ***p<0.001, one-way ANOVA with Fisher’s LSD test).