Figure 4. Li⁺ increases synaptic GluA2 and its associated scaffolding protein in vivo.

a) Representative immunoblots and b) quantitative analysis of hippocampal PSD from mice fed with normal mouse chow and Li⁺ chow for 7 days showing that Li⁺ increased GluA2/3, GRIP, and δ-catenin levels (n=8 animals, *p<0.05, unpaired two-tailed Student’s t tests). In vivo GSK3β inhibition by Li⁺ was confirmed by an increase in its phosphorylation and increased β -catenin levels.