Table 1.

Centers for disease control and prevention's diagnostic criteria for sCJD^∗.

A	B	C
(1) Myoclonus (2) Visual or cerebellar signs (3) Pyramidal/extrapyramidal signs (4) Akinetic mutism	(1) Periodic sharp wave complexes on EEG during an illness of any duration (2) Positive 14-3-3 CSF assay in patients with a disease duration of less than 2 years (3) MRI high signal abnormalities in caudate nucleus and/or putamen on diffusion weighted or fluid attenuation inversion recovery imaging	Routine investigations that do not indicate an alternative diagnosis

^∗Definite sCJD = diagnosed by standard neuropathological techniques; and/or immunocytochemically and/or Western blot confirmed protease-resistant PrP and/or presence of scrapie-associated fibrils.

Probable sCJD = rapidly progressive dementia + at least 2 of (A) + at least 1 of (B) + (C).

Possible sCJD = progressive dementia with duration of illness less than 2 years + at least 2 of (A) + none of (B) + (C).