Table 4.
Fever Clearance Time (in hours) for 4 Enteric Fever Patient Populations by Treatment
| Population | Culture Negative | Culture Positive | Salmonella Typhi | Salmonella Paratyphi A | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Median FCT (IQR) | Range | N | Median FCT (IQR) | Range | N | Median FCT (IQR) | Range | N | Median FCT (IQR) | Range | |
| Overall | 1178 | 41.3 (18.2–71.3) | 1.0–425.5 | 810 | 92.7 (65.3–124.7) | 1.0–496.0 | 549 | 92.0 (66.4–125) | 1.0–496.0 | 261 | 94.4 (56.1–122.8) | 1.0–349.0 |
| Treatment arm | ||||||||||||
| GAT | 585 | 39.1 (17.0–68.0) | 1.0–285.9 | 416 | 90.9 (64.3–116.9) | 1.0–349.0 | 283 | 90.8 (67.4–117.3) | 1.0–309.6 | 133 | 91.9 (55.8–116.0) | 6.8–349.0 |
| CFX | 96 | 66.5 (18.5–134.5) | 4.0–324.0 | 69 | 134.0 (82.0–205.0) | 16.0–496.0 | 47 | 140.0 (96.0–232.0) | 40.0–496.0 | 22 | 100.0 (81.0–164.0) | 16.0–214.0 |
| CRO | 62 | 102.3 (31.5–161.5) | 1.0–354.3 | 54 | 73.5 (46.0–112.8) | 7.8–232.8 | 38 | 82.6 (54.0–117.5) | 7.8–215.4 | 16 | 53.1 (43.3–83.0) | 7.8–232.8 |
| CHL | 239 | 41.5 (20.2–68.7) | 1.0–304.5 | 169 | 94.2 (65.2–136.3) | 2.8–327.4 | 120 | 89.8 (65.2–121.7) | 2.8–327.4 | 49 | 114.7 (63.4–151.6) | 4.4–262.8 |
| OFX | 196 | 36.8 (17.9–66.4) | 1.0–425.5 | 102 | 94.8 (56.0–122.3) | 1.0–311.8 | 61 | 89.8 (48.0–115.4) | 3.6–189.8 | 41 | 104.4 (71.5–141.6) | 1.0–311.8 |
Abbreviations: CFX, cefixime; CHL, chloramphenicol; CRO, ceftriaxone; FCT, fever clearance time; GAT, gatifloxacin; IQR, interquartile range; OFX, ofloxacin.