A, Human coronavirus strain. Seasonal distribution of human coronavirus lower respiratory tract disease (LRTD). B, Respiratory copathogens in human coronavirus LRTD. Each color indicates category of copathogen as follows: white (viruses), gray (fungi), and dark gray (bacteria). Respiratory viral copathogens were detected in 12 patients, fungal copathogens were detected in 10 patients, and bacterial copathogens were detected in 8 patients. The number of patients (n = 30) with other respiratory copathogens does not equal the sum of detections for each respiratory copathogen (n = 36) owing to codetections of multiple copathogens in some subjects.Abbreviations: ADV, adenovirus; A. fumigutus, Aspergillus fumigatus; B. cepacia, Burkholderia cepacia; CMV, cytomegalovirus; C. neoformans, Cryptococcus neoformans; E. faecium, Enterococcus faecium; H. influenzae, Haemophilus influenzae; HMPV, human metapnuemovirus; NT, nontypeable strain due to unavailable sample; P. aeruginosa, Pseudomonas aeruginosa; PIV, parainfluenza virus; PJP, Pneumocystis jirovecii; RSV, respiratory syncytial virus; RV, rhinovirus; S. aureus, Staphylococcus aureus; VGS, Viridans group streptococci.