Table 5.
Univariable Cox Regression Analysis for Overall Mortality by Day 90 After Diagnosis of Lower Respiratory Tract Disease (n = 286)
| Covariates | Category | Hazard Ratio (95% CI) |
P Value |
|---|---|---|---|
| Cell source | Peripheral blood stem cell | 1 | |
| Bone marrow | 1.69 (1.22–2.36) | <.01 | |
| Cord | 0.51 (.16–1.62) | .25 | |
| Transplant year | 1993–2006 | 1 | |
| 2007–2015 | 0.87 (.60–1.25) | .45 | |
| Respiratory copathogen | None | 1 | |
| Nonrespiratory virusa ± bacteria/fungi | 1.61 (.93–2.80) | .09 | |
| Bacteria/fungi | 1.54 (1.09–2.19) | .02 | |
| Days between transplant and diagnosis | ≤30 | 1 | |
| 31–365 | 0.94 (.65–1.34) | .71 | |
| >365 | 0.55 (.32–.94) | .03 | |
| White blood cell count, 106 cells/L | ≤1.0 | 1.69 (1.21–2.37) | <.01 |
| >1.0 | 1 | ||
| Neutrophil count, 106 cells/L | <0.5 | 1.76 (1.26–2.47) | <.01 |
| ≥0.5 | 1 | ||
| Lymphocyte count, 106 cells/L | <0.3 | 1.63 (1.17–2.29) | <.01 |
| ≥0.3 | 1 | ||
| Monocyte count, 106 cells/L | <0.3 | 2.38 (1.53–3.70) | <.01 |
| ≥0.3 | 1 | ||
| Steroid use within 2 weeks before diagnosis | No | 1 | |
| <1 mg/kg | 0.96 (.62–1.47) | .85 | |
| 1–2 mg/kg | 1.48 (1.00–2.20) | .05 | |
| >2 mg/kg | 2.23 (1.16–4.27) | .02 | |
| Oxygen use at diagnosis | No | 1 | |
| Any | 2.51 (1.72–3.66) | <.01 | |
| Respiratory virus | Respiratory syncytial virus | 1 | |
| Parainfluenza virus | 1.16 (.81–1.68) | .42 | |
| Influenza virus | 1.08 (.63–1.84) | .78 | |
| Human coronavirus | 1.32 (.69–2.53) | .40 |
Abbreviation: CI, confidence interval.
a Cytomegalovirus, herpes simplex virus, human herpesvirus 6, and Epstein-Barr virus.