Figure 5.

Inhibitory sigmoid maximum effect (E_max) curve demonstrating the pharmacokinetic/pharmacodynamic relationship of isavuconazole area under the concentration-versus-time curve over half-maximal effective concentration (AUC:EC₅₀) and galactomannan index (GMI) values at the end of treatment (terminal GMI). Logistic regression resulted in an r² of 0.237. Solid line represents the sigmoid curve fit of the model to the data, black squares represent the observed GMI values for each patient, and GMI negative value is included as a dotted line.