Table 3. Cytotoxic and mutagenic potential of grape, plum and orange flavourings determined in femoral bone marrow cells of mice (Mus musculus) treated orally for seven days.
| Group | (V/m)/(mL/kg) | Cytotoxic activity | MNF |
|---|---|---|---|
| Negative control | No treatment | 1.12±0.32 | 3±2.5 |
| Positive control | Cyclophosphamide | (0.5±0.11)a | (15.3±4.2)a |
| Grape flavouring | 0.5 1.0 |
(0.6±0.09)a (0.5±0.12)a |
(10.66±9.85)a (23.0±4.4)a |
| Plum flavouring | 0.5 1.0 |
(0.7±0.14)a (0.7±0.07)a |
3.33±2.06 3.16±0.75 |
| Orange flavouring | 0.5 1.0 |
(0.25±0.2)a (0.2±0.1)a |
1.8±1.5 5.7±3.2 |
V=volume of the flavouring solution, m=mass of the used animal, MNF=micronucleus frequency. ANOVA followed by Tukey´s test: asignificant compared to the negative control at p<0.05