Table 3.

Multivariable analysis of pathological and molecular variables against overall survival

	Wald statistic	OR	95%CI (lower)	95%CI (upper)	P value
T stage	1.735	1.392	0.851	2.279	0.188
N stage	0.268	0.857	0.479	1.535	0.605
EMVI	9.422	4.041	1.657	9.857	0.002
CIMP status	0.982	0.791	0.498	1.257	0.322
KRAS status	2.162	1.740	0.832	3.640	0.141
Sex	0.439	0.764	0.344	1.695	0.508
Local recurrence	0.861	1.763	0.532	5.839	0.353
Systemic recurrence	2.165	1.729	0.834	3.584	0.141
Tumour regression (pCR)	0.052	0.793	0.109	5.785	0.819
Involved CRM	0.146	1.339	0.299	6.002	0.703

CRM: Circumferential resection margin; CIMP: CpG island methylator phenotype; EMVI: Extramural vascular invasion; pCR: Pathological complete response.