Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 May 14;23(18):3240–3251. doi: 10.3748/wjg.v23.i18.3240

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

PMC Copyright notice

Thiopurines do not alter CD4+ helper T cell subsets. Peripheral blood mononuclear cells from healthy controls (open grey circles) vs inflammatory bowel disease (IBD) patients on (black triangles) vs not on thiopurines (grey squares) were stimulated and stained for ICCS as per materials and methods. As CD4 is down-regulated in response to PMA[37], CD3+, CD8- T cells were analyzed as a surrogate for CD4 expression. The percent of such cells expressing IL-17 (A, Th17 cells), IFN-γ (B, Th1 cells) or both (C, Th1/17 cells), and the percent of CD3+, CD8+ T cells expressing IFN-γ (D) is shown for each cohort. P values reflect two-tailed Mann-Whitney non-parametric comparisons.