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. 2017 May 14;23(18):3240–3251. doi: 10.3748/wjg.v23.i18.3240

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Thiopurine-associated lymphopenia is due to decreased NK cells. CD3- lymphocytes (A) and CD56+, CD19- subsets thereof (B-F) per milliliter of blood were calculated from flow cytometry performed on PBMC from healthy controls (open grey circles) vs IBD patients on (black triangles) vs not on thiopurines (grey squares). Total CD56+ NK (B) and CD16+ (C), NKp46+ (D), CD56^low (E), and CD56^high fractions thereof are shown. P values reflect two-tailed Mann-Whitney non-parametric comparisons.