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. 2017 May 14;23(18):3240–3251. doi: 10.3748/wjg.v23.i18.3240

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Intestinal B, but not T cells, are reduced in thiopurine recipients. Collagenase-digested colon biopsies from healthy controls (open grey circles) vs inflammatory bowel disease patients on (black triangles) vs not on thiopurines (grey squares) underwent flow cytometry. The percent of lymphocytes expressing the T cell marker CD3 (A) and the CD4:CD8 ratio thereof (B) is shown for each cohort. The percent of lymphocytes expressing the B cell marker CD19 (C) and the CD27-, CD38+, IgD+ or CD27-, CD38-, IgD+ fractions thereof resembling transitional (D) and naïve (E) B cells, respectively, are shown. The fraction of CD27+, IgD-, CD20+, CD38- memory B cells (F) and CD27+, CD38+, CD20-, IgD- plasma cells (G) expressing surface IgM is shown. P values reflect two-tailed Mann-Whitney non-parametric comparisons.