Table 3.
Results of irritable bowel syndrome-symptom severity system response in subgroups of inflammatory bowel disease patients on low FODMAP
| Number | Week 0 | Week 6 | P value | |
| Ulcerative colitis (UC) | ||||
| UC | 55 (71) | 220 (190-300) | 124 (40-198) | < 0.01 |
| LFD | 26 (47) | 225 (187-260) | 120 (36-170) | < 0.01 |
| ND | 29 (53) | 220 (185-315) | 141 (52-263) | < 0.01 |
| 0.371 | ||||
| Crohn’s disease (CD) | ||||
| CD | 23 (29) | 245 (170-320) | 170 (56-294) | < 0.01 |
| LFD | 11 (48) | 210 (160-320) | 58 (18-173) | 0.02 |
| ND | 12 (52) | 250 (172-382) | 220 (57-357) | 0.54 |
| 0.021 | ||||
| UC vs CD, P = 0.241 | ||||
| IBD-Remission by SCCAI/HBI | ||||
| Remission | 65 (83) | 230 (175-305) | 140 (39-212) | < 0.01 |
| LFD | 31 (48) | 220 (170-250) | 105 (26-167) | < 0.01 |
| ND | 34 (52) | 242 (177-322) | 175 (77-298) | < 0.01 |
| < 0.011 | ||||
| IBD Mild-to-Moderate Activity by SCCAI/HBI | ||||
| Activity | 13 (17) | 210 (200-350) | 140 (103-252) | 0.53 |
| LFD | 6 (46) | 210 (194-391) | 169 (105-332) | 0.17 |
| ND | 7 (54) | 260 (200-330) | 140 (96-211) | 0.06 |
| 0.531 | ||||
| Remission vs Activity, P < 0.011 | ||||
| FC-remission (≤ 100 μg/g UC, ≤ 200 μg/g CD), n = 53 | ||||
| Remission | 53 (73) | 220 (179-305) | 113 (34-225) | < 0.01 |
| LFD | 25 (47) | 220 (174-305) | 60 (29-169) | < 0.01 |
| ND | 28 (53) | 230 (180-307) | 174 (66-298) | < 0.01 |
| 0.061 | ||||
| FC-activity (> 100 μg/g UC; > 200 μg/g CD), n = 20 | ||||
| Activity | 20 (27) | 250 (204-330) | 160 (110-211) | < 0.01 |
| LFD | 11 (55) | 210 (200-250) | 157 (95-198) | 0.04 |
| ND | 9 (45) | 320 (230-360) | 170 (103-291) | 0.03 |
| 0.501 | ||||
| FC-Remission vs FC-Activity, P = 0.291 | ||||
| CRP-remission (< 10 mg/L), n = 75 | ||||
| Remission | 75 (96) | 230 (180-320) | 140 (50-211) | < 0.01 |
| LFD | 35 (47) | 210 (187-260) | 114 (30-169) | < 0.01 |
| ND | 40 (53) | 248 (180-320) | 176 (78-288) | < 0.01 |
| < 0.011 | ||||
| CD, prior surgery (bowel/ileo-coecal resections), n = 13/23 (57%) | ||||
| LFD | 11 | 225 (178-302) | 10 (32-223) | < 0.01 |
| ND | 2 | - | - | |
1
P: Mann-Whitney U test comparison of change in outcomes between treatment groups at 6-wk. All data are presented as median (IQR: Interquartile range), n (%) (- only 2 cases). P: Wilcoxon signed rank test, comparison of paired samples within each treatment group. IBS: Irritable bowel syndrome; SSS: Severity score system; IBD: Inflammatory bowel disease; LFD: Low FODMAP diet; ND: Normal Diet.