Table 3.

Association between a genetically predicted PR interval and atrial fibrillation.

Data set	Subjects	Cases/Controls	OR (95% CI)*	P-value
eMERGE	All AF cases	1,547 / 3,128	0.89 (0.83–0.95)	0.0006
	All AF cases, GRS adjusted†	1,547 / 3,128	0.90 (0.83–0.98)	0.02
	All AF cases, SNP adjusted‡	1,547 / 3,128	0.90 (0.81–1.01)	0.06
BioVU EHR set	All AF	1,206 / 2,405	0.90 (0.85–0.98)	0.01
BioVU AF registry	All AF	1,022 / 668	0.90 (0.81–0.99)	0.03
	Lone AF	220 / 668	0.87 (0.74–1.03)	0.1
	Paroxysmal	444 / 668	0.90 (0.80–1.02)	0.09
	Persistent	259 / 668	0.93 (0.80–1.08)	0.34

^*The odds-ratio is per standard deviation increase in the genetically predicted PR interval. All association models are adjusted for age, gender and 3 PCs.

^†Adjusted for genetic risk scores for atrial fibrillation and the PR interval.

^‡Adjusted for SNPs (n=17) previously associated with AF or the PR interval by GWAS.