Figure 2.

CNDP1 (CTG)_n genotype distribution in T2DM patients. Genotype distribution is depicted as homozygosity for the (CTG)₅ allele (10 leucine) versus all other genotypes (≥11 leucine). Planned comparisons were carried out between T2DM patients without DN and with either CIC- or BP-defined nephropathy. (a) No significant difference in genotype distribution was observed between T2DM patients with DN and without DN when applying CIC. The frequency of patients homozygous for the (CTG)₅ allele decreased when BP-DN was considered. However, this difference did not hold after Bonferroni correction. ((b) and (c)) Gender stratification ((b) male patients, (c) female patients) showed no significant difference in the frequency of homozygosity for the CNDP1 (CTG)₅ allele between T2DM with and without DN when applying CIC. When DN was confirmed through biopsy, however, the frequency of CNDP1 (CTG)₅ homozygosity significantly decreased in female T2DM patients, which remained significant after Bonferroni adjustment.