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CN-1 activities decrease with time on dialysis. (a) Serum CN-1 activity was assessed in 175 hemodialysis patients and plotted against the log-transformed duration since hemodialysis was initiated. A significant correlation between serum CN-1 activity and log-transformed hemodialysis duration was found in all patients. ((b) and (c)) After stratification in T2DM (b) and other causes of renal failure (c), the correlation remained significant. HD: hemodialysis.
