Table 1.
Demographic and clinical data of all patients.
| No-DN | CIC-DN | BP-DN | CIC-NDRD | BP-NDRD | |
|---|---|---|---|---|---|
| N | 130 | 108 | 30 | 80 | 22 |
| Demographic characteristics | |||||
| Male sex—n (%) | 65 (50) | 69 (64) | 21 (70) | 49 (61) | 14 (64) |
| Age—year | 71 (63–75) | 71 (62–76) | 61 (57–69) | 61 (48–74) | 61 (55–78) |
| Clinical characteristics | |||||
| Body mass index—kg/m2 | 31.1 (28–35) | 29.8 (27–35) | 29.9 (25–35) | 24.5 (21–27) | 27 (24–32) |
| Hypertension | |||||
| Number of AHM | 3 (2–3) | 3 (2–4) | 3 (2–5) | 3 (1.5–4) | 2 (2–4) |
| Blood pressure—mmHg | |||||
| Systolic | 129 (120–140) | 135 (120–156) | 140 (130–150) | 135 (120–145) | 140 (128–153) |
| Diastolic | 70 (66–80) | 70 (60–80) | 75 (70–80) | 70 (60–80) | 70 (64–80) |
| Diabetes mellitus | |||||
| Time from diagnosis—year | 16 (13–20) | 21 (15–29) | 14 (9–20) | — | — |
| HbA1c—% | 7.0 (6.4–8.1) | 7.3 (6.8–8.2) | 7.6 (6.7–8.8) | 5.6 (5.4–5.7) | 5.6 (5.1–6.2) |
| Kidney function | |||||
| Creatinine—mg/dl | 0.9 (0.8–1.1) | 6.3 (3.7–8.8) | 5.7 (3.0–7.3) | 9.7 (7.5–11.5) | 3.4 (1.7–5.0) |
| eGFR—ml/min | 73 (61–87) | 9 (6–16) | 10 (6–20) | 5 (4–8) | 15 (8–37) |
| Hemodialysis—n (%) | 0 (0) | 83 (75) | 18 (60) | 85 (100) | 8 (36) |
| HD duration—months∗ | 0 (0–0) | 26 (1–69) | 3 (0–30) | 56 (28–100) | 0 (0–0.3) |
| Albuminuria—mg/l | 9 (5–16) | 644 (327–2110) | 2070 (337–3290) | 470 (261–1587) | 556 (189–1308) |
| Retinopathy (DR)—n (%) | |||||
| No DR | 107 (82) | 1 (0) | 6 (20) | — | — |
| NPDR | 23 (18) | 68 (63) | 11 (37) | — | — |
| Proliferative DR | — | 17 (16) | 4 (13) | — | — |
| Maculopathy | — | 8 (7) | 3 (10) | — | — |
| Laser therapy | — | 13 (12) | 3 (10) | — | — |
| Polyneuropathy—n (%) | 54 (42) | 56 (52) | 17 (57) | — | — |
| History—n (%) | |||||
| Coronary heart disease | 42 (32) | 74 (69) | 11 (37) | 24 (30) | 6 (22) |
| Cardiovascular event | 20 (15) | 42 (39) | 7 (23) | 14 (18) | 5 (23) |
| Arterial occlusive disease | 24 (18) | 56 (52) | 11 (37) | 17 (21) | 3 (14) |
| Stroke | 19 (15) | 28 (26) | 6 (20) | 8 (10) | 2 (9) |
| Statin | 86 (66) | 79 (73) | 19 (63) | 28 (35) | 10 (45) |
| Homozygous CTG5—n (%) | 47 (36) | 41 (38) | 5 (17) | 32 (40) | 7 (32) |
∗Patients on hemodialysis only. Categorical data are represented as numbers (%) and continuous data as median with corresponding 25th and 75th percentiles (IQR). AHM: antihypertensive medication; eGFR: estimated glomerular filtration rate; HD: hemodialysis; DR: diabetic retinopathy; NPDR: nonproliferative diabetic retinopathy.