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. 2017 Apr 4;108(4):431–437. doi: 10.1093/jhered/esx033

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© The American Genetic Association. 2017.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Key features of interacting components for juxtaposing the start codon against the anticodon of the initiating fMet-tRNA^fMet. (a) A model of SD/aSD pairing. Two different SDs on mRNA (SD₁ and SD₂), with different distances (D₁ and D₂, respectively) to the initiation codon AUG can both properly align AUG against the tRNA. The 2 different SD/aSD pairings result in the same D_toStart, defined as the distance between th’e 3′ end of ssu rRNA to the start codon. (b) A sample of SD/aSD pairing from highly expressed Escherichia coli genes, with the start codon and the tRNA anticodon in small case. (c) One example of a highly expressed gene (rpsQ) with 2 putative SDs (c). Gene IDs are in the form of “gene name/Locus_tag”. SDs in (b) and (c) differ in sequence and distance to the start codon, but they all have similar D_toStart. A change in D_toStart will lead to misalignment of start codon and tRNA anticodon.