Figure 3.

Fitting an effective number of independent categories. The multiple category p-value, p_multiple, versus p-value for the data set of van 't Veer et al. [13], using 327 large Gene Ontology categories with more than 20 genes. The yellow band shows 95% confidence interval of sample label permutation results, based on 1000 random lists, and the blue curves show the results of Equation (1), with the fitted N_eff = 152 (solid line), the total number of categories N = 327 (dashed line), and also the Bonferroni correction (dotted line).